Ion Mobility Spectrometry

Quick Note:
- Ambient pressure ionization
- Low electric field
- Not for samples with complex matrix
IMS (Ion Mobility Spectrometry)
Pros

• can quantify amounts of sample less than a nanogram 
• Good sensitivity and High sample throughput

Cons

• Not appropriate for complex samples 

Instruments:
IONSCAN-LS Smiths Detection
 - Ni 63 foil radioactive Ionization source
SPE (Solid Phase Extraction)
- Classical SPE supports: C18 for cocaine in urines.